Publications by authors named "J Petrovic"
Understanding the molecular pathogenesis of MLL fusion oncoprotein (MLL-FP) leukaemia has spawned epigenetic therapies that have improved clinical outcomes in this often-incurable disease. Using genetic and pharmacological approaches, we define the individual and combined contribution of KAT6A, KAT6B and KAT7, in MLL-FP leukaemia. Whilst inhibition of KAT6A/B is efficacious in some pre-clinical models, simultaneous targeting of KAT7, with the novel inhibitor PF-9363, increases the therapeutic efficacy.
View Article and Find Full Text PDFThe thyroid gland has an important influence on the heart. Long-term exposure to high levels of thyroid hormones may lead to cardiac hypertrophy and dysfunction. The aim of the study was to evaluate the morphological and functional changes in the left ventricle in patients with hyperthyroidism caused by Graves' disease (GD) in comparison with healthy individuals, as well as to investigate potential differences in these parameters in GD patients in relation to the presence of orbitopathy.
View Article and Find Full Text PDFTo improve dental care for individuals with special needs, it is crucial to understand the effectiveness of endodontic treatments under general anaesthesia. This systematic review explores the feasibility, prognostic factors, and outcomes of root canal treatment and pulpotomy performed under general anaesthesia in adult and adolescent patients with special needs. A comprehensive search of Cochrane Library and MEDLINE databases was conducted until July 2024.
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- The report analyzes data on the treatment of peripheral artery disease (PAD) in Serbia, focusing on factors like sex differences, types of revascularization, and associated health outcomes.
- A total of 1681 PAD patients from 27 hospitals were evaluated, revealing that men represented a larger portion of the patient group and had a higher likelihood of undergoing surgical treatments compared to women.
- The findings underscore the significance of diabetes and smoking in PAD progression, highlighting increased risks for complications and mortality, especially in diabetic patients, while suggesting that certain treatments may lower the need for more invasive procedures like major amputations.
Article Synopsis
- * A study involving 108 patients revealed that 63% experienced improvement in mitral regurgitation after isolated aortic valve replacement, with variances in outcomes based on patient-prosthesis mismatch.
- * Results indicate that avoiding patient-prosthesis mismatch leads to better hemodynamic outcomes and reduces the chance of persistent mitral regurgitation, potentially minimizing the necessity for further mitral valve surgery.