Orthostatic Resiliency During Successive Hypoxic, Hypoxic Orthostatic Challenge: Successful vs. Unsuccessful Cardiovascular and Oxygenation Strategies.

Rapid environmental changes, such as successive hypoxic-hypoxic orthostatic challenges (SHHOC) occur in the aerospace environment, and the ability to remain orthostatically resilient (OR) relies upon orchestration of physiological counter-responses. Counter-responses adjusting for hypoxia may conflict with orthostatic responses, and a misorchestration can lead to orthostatic intolerance (OI). The goal of this study was to pinpoint specific cardiovascular and oxygenation factors associated with OR during a simulated SHHOC.

Limb Skin Temperature as a Tool to Predict Orthostatic Instability.

Orthostatic instability is one of the main consequences of weightlessness or gravity challenge and plays as well a crucial role in public health, being one of the most frequent disease of aging. Therefore, the assessment of effective countermeasures, or even the possibility to predict, and thus prevent orthostatic instability is of great importance. Heat stress affects orthostatic stability and may lead to impaired consciousness and decrease in cerebral perfusion, specifically during the exposure to G-forces.

The evolution of rhPDGF-BB in musculoskeletal repair and its role in foot and ankle fusion surgery.

Platelet-derived growth factor (PDGF) is one of the most thoroughly studied proteins in the body. Research has progressively highlighted the role of PDGF during wound healing and in the bone repair cascade. This research has resulted in FDA approval of 2 products containing a recombinant version of the protein, rhPDGF-BB, for treating chronic diabetic foot ulcers and periodontal bone defects.

LBNP and push-pull effect.

The high level of the long lasting acceleration with both an extensive gradient of the acceleration onset and vector alterations belong to the flight specificity in a cockpit of agile aircraft with high manoeuvring capabilities. In these cases the so-called push-pull (PP) effect has its particular significance. This means the tolerance decrease to the plus gravitational acceleration turns up after an exposure to the microgravity on the acceleration level between zero and +0.

Testing method of plus and minus Gz tolerance at Czech Air Force pilots.

Pilots' physiological measurement in conditions of alternating plus and minus Gz (gravitational acceleration) has been done during real flights. The comparison of physiological responses during flights at the safe altitude of 7000 ft and low level flights at the altitude of 900 ft over ground bears on the evaluation of changes of the continuous blood pressure and the heart rate. High level of pilots' plus-minus Gz tolerance is essential requirement to cope with low level flights in agile aircraft.