Publications by authors named "J Peter Lodge"
Loeffler first described "fibroplastic parietal endocarditis with blood eosinophilia" in 1936. This we now know refers to the most common cardiac manifestation of an uncommon condition, the so-called hypereosinophilic syndromes. This condition typically results in a restrictive cardiomyopathy affecting the left heart, but here, we present an unusual case of a 65-year-old woman with chronic hypereosinophilia of at least 2 years, who presented with right heart failure as a result of eosinophilic endomyocardial infiltration of her right ventricle.
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- - The text discusses the need for better communication on research ethics due to emerging technologies, highlighting that academic articles often fail to adequately express these ethical concerns.
- - It outlines a project that aims to create new editorial policies for how research ethics should be addressed in scholarly publications, especially in the context of learning and technology.
- - The findings reveal significant gaps in current journal policies, with over half lacking ethical statements and many papers not addressing ethical considerations, leading to the development of materials designed for cross-disciplinary application to improve research involving AI and emerging technologies.
Glioblastoma (GBM) is a deadly brain cancer. The prognosis of GBM patients has marginally improved over the last three decades. The response of GBMs to initial treatment is inevitably followed by relapse.
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- Host cell proteins (HCPs) are unwanted contaminants found in biotherapeutics derived from engineered living systems, affecting their quality, effectiveness, and safety.
- Liquid chromatography-mass spectrometry (LC-MS) is a technique used to detect HCPs, but the presence of abundant biotherapeutics makes it challenging to identify low-level HCPs.
- The study adapted a technique called native digestion for use with adeno-associated viruses (AAV) to improve HCP extraction, demonstrating that this approach outperformed denaturing methods in isolating HCPs linked to various AAV serotypes.
Somatostatin peptides prevent increased human colonic epithelial permeability induced by hypoxia.
Am J Physiol Gastrointest Liver Physiol
November 2024
Mesenteric ischemia increases gut permeability and bacterial translocation. In human colon, chemical hypoxia induced by 2,4-dinitrophenol (DNP) activates basolateral intermediate conductance K (IK) channels (designated KCa3.1 or KCNN4) and increases paracellular shunt conductance/permeability (), but whether this leads to increased macromolecule permeability is unclear.
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