Publications by authors named "J Penney"
Article Synopsis
- * Treatments for Parkinson's and similar conditions are limited, partly because of unclear underlying mechanisms of the diseases.
- * Microglia, the brain's immune cells, are increasingly recognized as playing a crucial role in neuroinflammation and the progression of Parkinson's, influenced by genetic factors and mutations related to the disease.
Kiezdeutsch is a multiethnolectal variety of German spoken by young people from multicultural communities that exhibits lexical, syntactic, and phonetic differences from standard German. A rather salient and pervasive feature of this variety is the fronting of the standard palatal fricative /ç/ (as in "I") to [ɕ] or [ʃ]. Previous perception work shows that this difference is salient and carries social meaning but dependent on the listener group.
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- Tuberculous meningitis (TBM) is a major health issue in Botswana, especially linked to high HIV rates, and prior to 2016, TB testing was limited to mycobacterial cultures, making diagnosis difficult.
- The introduction of the GeneXpert platform significantly improved TB-specific investigations in cerebrospinal fluid samples, increasing from 4.5% to 29% from 2016 to 2022, as access to testing became more widespread.
- Despite a decline in total CSF samples analyzed, the proportion of microbiologically confirmed TBM cases rose slightly, indicating that better testing methods are leading to more accurate diagnoses in remote healthcare settings.
The kinetics of sulfur transfer from titanocene (poly)sulfides (CpTiS, CpTiSCMe, CpTi(SAr), CpTiCl(SAr)) to sulfenyl chlorides (SCl, RSCl) have been investigated by a combination of stopped-flow UV-Vis/NMR reaction monitoring, titration assays, numerical kinetic modelling and KS-DFT calculations. The reactions are rapid, proceeding to completion over timescales of milliseconds to minutes, a sequence of two S-S bond-forming steps ( , ). The archetypical polysulfides CpTiS (1a) and CpTiSC(Me) (2a) react with disulfur dichloride (SCl) through rate-limiting intermolecular S-S bond formation ( ) followed by a rapid intramolecular cyclization ( , with ≫ [RSCl]).
View Article and Find Full Text PDFThe physics of shear waves traveling through matter carries fundamental insights into its structure, for instance, quantifying stiffness for disease characterization. However, the origin of shear wave attenuation in tissue is currently not properly understood. Attenuation is caused by two phenomena: absorption due to energy dissipation and scattering on structures such as vessels fundamentally tied to the material's microstructure.
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