Publications by authors named "J Pawlonka"
Article Synopsis
- The renin-angiotensin-aldosterone system (RAAS) is essential for regulating cardiovascular health and is a target for various therapeutic drugs, especially in managing diseases like hypertension and heart failure.
- Dysregulation of RAAS has drawn attention in cancer treatment due to its impact on tumor biology and cardiovascular toxicities from oncological therapies.
- RAAS inhibitors (RAASi) could serve as supportive treatments that help mitigate cardiovascular risks and improve outcomes in cancer patients undergoing therapies that can lead to cardiovascular complications.
Cyclins are key regulators of cell cycle progression and survival. Particularly cyclins D (cyclin D1, D2, and D3) act in response to the mitogenic stimulation and are pivotal mediators between proliferative pathways and the nuclear cell cycle machinery. Dysregulation of cyclins expression results in impaired development, abnormal cell growth or tumorigenesis.
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