Asoprisnil as a Novel Ligand Interacting with Stress-Associated Glucocorticoid Receptor.

The glucocorticoid receptor (GR) is critical in regulating cortisol production during stress. This makes it a key target for treating conditions associated with hypothalamic-pituitary-adrenal (HPA) axis dysregulation, such as mental disorders. This study explores novel ligands beyond mifepristone for their potential to modulate GR with improved efficacy and safety.

Textile microfibers valorization by catalytic hydrothermal carbonization toward high-tech carbonaceous materials.

Microplastics fibers shed from washing synthetic textiles are released directly into the waters and make up 35% of primary microplastics discharged to the aquatic environment. While filtration devices and regulations are in development, safe disposal methods remain absent. Herein, we investigate catalytic hydrothermal carbonization (HTC) as a means of integrating this waste (0.

Flaviviruses manipulate mitochondrial processes to evade the innate immune response.

Mitochondria are essential eukaryotic organelles that regulate a range of cellular processes, from metabolism to calcium homeostasis and programmed cell death. They serve as essential platforms for antiviral signaling proteins during the innate immune response to viral infections. Mitochondria are dynamic structures, undergoing frequent fusion and fission processes that regulate various aspects of mitochondrial biology, including innate immunity.

The implication of ADRA2A and AVPRIB gene variants in the aetiology of stress-related bipolar disorder.

Objective: Bipolar disorder is a complex and severe mental illness characterised by manic and depressive episodes that can be triggered and exacerbated by psychosocial, environmental, and biological stressors. Genetic variations are a risk factor for bipolar disorder. However, the identification of the exact gene variants and genotypes remains complex.