[Verification of the hepatoprotective and therapeutic effect of silymarin in experimental liver injury with tetrachloromethane in dogs].

The efficiency of preventive administration of silymarin and of silymarin medication were tested in dogs suffering from CCl4 intoxication of liver. Sixteen dogs of the Beagle breed at the age of 8 to 10 months and of the weight 11.5 to 14.

[Determination of hepatotoxicity using the texture analysis method].

To determine the hepatotoxic effects of hydrazine sulphate by means of a complex of methods of morphological examinations, ten sheep were used as a model of acute liver lesions induced by this compound. The hepatotoxic effects were demonstrated by a general histological examination of liver tissue and by a quantitative evaluation of percent proportions of intact liver parenchyma. Among quantitative indicators, the areas of histochemically detectable neutral lipids and of glycogen in liver tissue were also evaluated.