Publications by authors named "J Paul Spin"
Article Synopsis
- - Genetic studies have linked numerous plasma proteins to abdominal aortic aneurysm (AAA), a serious vascular disease, but their causal effects were not well-explored prior to this research.
- - The study used two-sample Mendelian randomization (MR) on a massive dataset, analyzing 39,221 individuals with AAA and 1,086,107 without to identify 90 plasma proteins potentially impacting AAA, with 25 showing strong support from further analysis.
- - Notable proteins like PCSK9, LTBP4, and COL6A3 were found to be associated with AAA, and gene ontology analyses revealed their roles in the extracellular matrix, suggesting a significant biological connection between these proteins and AAA risk.
Importance: Restrictions related to the COVID-19 pandemic disrupted the lives of young children, but the association between the pandemic and any changes in early childhood developmental milestone achievement in the US remains unclear.
Objectives: To determine the association between the COVID-19 pandemic and changes in developmental screening scores among US children aged 0 to 5 years and to investigate whether caregivers self-reported more worries about their children or concerns about children's behavior during the pandemic, regardless of milestone achievement.
Design, Setting, And Participants: This was a cohort study using an interrupted time series analysis comparing prepandemic (March 1, 2018, to February 29, 2020), interruption (March 1 to May 31, 2020), and intrapandemic (June 1, 2020, to May 30, 2022) periods among 50 205 children (randomly sampled from a population of 502 052 children) aged 0 to 5 years whose parents or caregivers completed developmental screening at pediatric visits at US pediatric primary care practices participating in a web-based clinical process support system.
Background: The ATP2B1 gene encodes for a calcium pump, which plays a role in removing Ca2+ from cells and maintaining intracellular Ca2+ homeostasis. Reduction of the intracellular Ca2+ concentration in CD4+ T cells is thought to reduce the severity of colitis, while elevation of Ca2+ in CD4+ T cells induces T cell hyperactivity. Our aim was to clarify the role of ATP2B1 in CD4+ T cells and in inflammatory bowel disease development.
View Article and Find Full Text PDFAims: Abdominal aortic aneurysm (AAA) is a highly lethal disease with progressive dilatation of the abdominal aorta accompanied by degradation and remodelling of the vessel wall due to chronic inflammation. Platelets play an important role in cardiovascular diseases, but their role in AAA is poorly understood.
Methods And Results: The present study revealed that platelets play a crucial role in promoting AAA through modulation of inflammation and degradation of the extracellular matrix (ECM).