Publications by authors named "J Patrick Kampf"
Impact of smoking on procedural outcomes and all-cause mortality following acute myocardial infarction: A misleading early-stage pseudoparadox with ultimately reduced survival.
Int J Cardiol Cardiovasc Risk Prev
December 2024
Article Synopsis
- The study focused on how smoking impacts outcomes for patients who experienced acute myocardial infarction (AMI), looking specifically at death rates over a follow-up period of about 1.14 years.
- Among 1612 AMI patients, current smokers had a higher long-term mortality rate (56% more) compared to non-smokers, while ex-smokers had similar outcomes to non-smokers.
- The findings suggest that active smoking leads to worse outcomes in terms of survival and earlier onset of heart-related issues, such as STEMI, compared to those who do not smoke.
Background And Aims: Current ESC guidelines on the management of patients after acute myocardial infarction only include the evaluation of left ventricular (LV) function by assessment of the ejection fraction in addition to clinical risk scores to estimate the patient's prognosis. We aimed to determine, whether comprehensive evaluation of cardiac function using LV and right ventricular (RV) global longitudinal strain (GLS) and left atrial (LA) reservoir strain improves the prediction of survival in patients with acute myocardial infarction.
Methods: In patients with non-ST segment elevation or ST segment elevation myocardial infarction receiving echocardiography within 1 year after revascularisation, LV-GLS, RV-GLS and LA reservoir strain were quantified.
Article Synopsis
- Nitroso compounds (RNO) are byproducts of drug metabolism that interact with heme proteins, forming stable complexes which can serve as models for unstable heme-HNO intermediates critical in the nitrogen cycle.
- A series of six-coordinate ferrous heme-RNO complexes were synthesized and characterized using various methods, including nuclear resonance vibrational spectroscopy, shedding light on their vibrational properties compared to HNO analogs.
- While these complexes are stable and do not react with NO or exhibit significant reactivity with Lewis acids, their behavior indicates that they are unsuitable models for studying the reactivity of heme-HNO complexes.
This paper describes detailed organometallic studies of the aminoquinoline-directed Ni-catalyzed C-H functionalization of 2,3,4,5-tetrafluoro--(quinolin-8-yl)benzamide with diaryliodonium reagents. A combination of F NMR spectroscopy and X-ray crystallography is used to track and characterize diamagnetic and paramagnetic intermediates throughout this transformation. These provide key insights into both the cyclometalation and oxidative functionalization steps of the catalytic cycle.
View Article and Find Full Text PDFPurpose: Urinary C-C motif chemokine ligand 14 (CCL14) is a strong predictor of persistent stage 3 acute kidney injury (AKI). Multiple clinical actions are recommended for AKI but how these are applied in individual patients and how the CCL14 test results may impact their application is unknown.
Methods: We assembled an international panel of 12 experts and conducted a modified Delphi process to evaluate patients at risk for persistent stage 3 AKI (lasting 72 hours or longer).