[The effects of sodiumnitroprusside and trimethaphan induced hypotension on haemodynamics and myocardial oxygen consumption (author's transl)].

The influence of controlled hypotension (mean arterial pressure 60 mmHg) induced by sodium nitroprusside and trimethaphan on systemic circulation and myocardial oxygen consumption was studied in 7 anaesthetized closed chest dogs. The hypotensive effect of both drugs was primarily mediated by a reduction in total peripheral resistance. No change in cardiac output was observed.

Effect of althesin on renal perfusion in anaesthetized dogs.

Since Althesin affects not only the systemic circulation but also certain regional blood flows autoregulated by intrinsic mechanisms, such as cerebral and coronary blood flow, the purpose of this study was to investigate the effect of Althesin upon renal blood flow. After an injection of 2.0 mg/kg Althesin, heart rate (63 per cent) and cardiac output (21 per cent) increased, while total peripheral resistance (25 per cent), mean aortic pressure (9 per cent) and the maximum rate of change of left ventricular pressure (31 per cent) decreased.