Publications by authors named "J Pasantes"

Unlabelled: Research on bivalves is fast-growing, including genome-wide analyses and genome sequencing. Several characteristics qualify oysters as a valuable model to explore repetitive DNA sequences and their genome organization. Here we characterize the satellitomes of five species in the family Ostreidae (), revealing a substantial number of satellite DNAs (satDNAs) per genome (ranging between 33 and 61) and peculiarities in the composition of their satellitomes.

View Article and Find Full Text PDF

Cancer is a multifaceted genetic disease characterized by the acquisition of several essential hallmarks. Notably, certain cancers exhibit horizontal transmissibility, observed across mammalian species and diverse bivalves, the latter referred to as hemic neoplasia. Within this complex landscape, epigenetic mechanisms such as histone modifications and cytosine methylation emerge as fundamental contributors to the pathogenesis of these transmissible cancers.

View Article and Find Full Text PDF
Article Synopsis
  • - Transmissible cancers like bivalve transmissible neoplasia (BTN) can spread between marine organisms, particularly affecting species like the common cockle (Cerastoderma edule) along the Atlantic coasts of Europe and Africa.
  • - Researchers examined over 6,800 cockles, diagnosed 390 cases of BTN tumors, and analyzed genomic variation in 61 tumors, confirming the presence of two BTN lineages with links to blood cell origins.
  • - The study found significant genomic instability in the BTN tumors, including whole-genome duplications and mutations, and suggested a long history of clonal evolution in these transmissible cancers.
View Article and Find Full Text PDF
Article Synopsis
  • * Researchers sequenced the genomes of eight warty venus clams with HN from two locations over 1000 nautical miles apart, revealing the presence of genetic material from two clam species.
  • * Phylogenetic analysis indicated that the leukaemia originated in striped venus clams and was transmitted to warty venus clams, where it continues to spread as a contagious cancer in the Southern European seas.
View Article and Find Full Text PDF

Several features already qualified the invasive bivalve species as a valuable non-standard model organism in genome research. is characterized by the low contribution of satellite DNAs (satDNAs) vs. mobile elements and has an extremely low amount of heterochromatin, predominantly built of DNA transposons.

View Article and Find Full Text PDF