Publications by authors named "J Partington"
Simultaneous identification and quantification of per- and polyfluoroalkyl substances (PFAS) were evaluated for three quadrupole time-of-flight mass spectrometry (QTOF) acquisition methods. The acquisition methods investigated were MS-Only, all ion fragmentation (All-Ions), and automated tandem mass spectrometry (Auto-MS/MS). Target analytes were the 25 PFAS of US EPA Method 533 and the acquisition methods were evaluated by analyte response, limit of quantification (LOQ), accuracy, precision, and target-suspect screening identification limit (IL).
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- Microsampling is a cost-effective and easy method for collecting blood samples that doesn't require specialized medical training.
- Analysis of dried blood spots (DBS) provides a better understanding of how per- and polyfluoroalkyl substances (PFAS) are present in the body.
- A study found that filtered protein precipitation was the best technique for extracting PFAS, successfully identifying 72 out of 75 PFAS and paving the way for more extensive human biomonitoring studies.
Article Synopsis
- In 2018, over 30,000 liters of fluorine-free firefighting foam were used to extinguish an industrial fire, leading to the contamination of a freshwater creek in Melbourne.
- The study employed nontarget analysis with advanced mass spectrometry to examine surface water samples and identified six new types of fluorosurfactants in the environment for the first time.
- Findings indicated that runoff from fluorinated firefighting foam significantly contributed to the presence of various per- and polyfluoroalkyl substances (PFAS) in the surrounding water, linking the contamination to the firefighting efforts.
Background: The use of the multicomponent meningococcal vaccine 4CMenB in the UK schedule at 2, 4, and 12 months of age has been shown to be 59·1% effective at preventing invasive group B meningococcal disease. Here, we report the first data on the immunogenicity of this reduced-dose schedule to help to interpret this effectiveness estimate.
Methods: In this multicentre, parallel-group, open-label, randomised clinical trial, infants aged up to 13 weeks due to receive their primary immunisations were recruited via child health database mailouts in Oxfordshire and via general practice surgeries in Gloucestershire and Hertfordshire.
A multimode self-mixing terahertz-frequency gas absorption spectroscopy is demonstrated based on a quantum cascade laser. A double-metal device configuration is used to expand the laser's frequency tuning range, and a precision-micromachined external waveguide module is used to enhance the optical feedback. Methanol spectra are measured using two laser modes at 3.
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