Publications by authors named "J Parraga"
Unlabelled: Cardiovascular diseases remain as the most common cause of death worldwide. To reveal the underlying mechanisms in varying cardiovascular diseases, in vitro models with cells and supportive biomaterial can be designed to recapitulate the essential components of human heart. In this study, we analyzed whether 3D co-culture of cardiomyocytes (CM) with vascular network and with adipose tissue-derived mesenchymal stem/stromal cells (ASC) can support CM functionality.
View Article and Find Full Text PDFDuring durst storms, also biological material is transported from arid areas such as the Sahara Desert. In the present work, rain samples containing significant amounts of mineral dust have been collected in Granada during different red rain episodes. Biological features (bacteria, biofilm, pollen grain and fungal spore) as well as size-particle distribution and mineralogical composition were studied by SEM.
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- Staphylococcus aureus is a bacteria that often causes lung infections, especially in people with chronic conditions.
- Scientists found that this bacteria can use a substance called sialic acid to grow better, especially when it doesn’t work well with its signaling system (quorum sensing).
- In patients with cystic fibrosis, researchers discovered that S. aureus often lives alongside bacteria that produce sialic acid, suggesting that sialic acid helps it become more harmful and survive longer in the lungs.
Chronic pain has increasingly become a significant health challenge, not just as a symptomatic manifestation but also as a pathological condition with profound socioeconomic implications. Despite the expansion of medical interventions, the prevalence of chronic pain remains remarkably persistent, prompting a turn towards non-pharmacological treatments, such as therapeutic education, exercise, and cognitive-behavioral therapy. With the advent of cognitive neuroscience, pain is often presented as a primary output derived from the brain, aligning with Engel's Biopsychosocial Model that views disease not solely from a biological perspective but also considering psychological and social factors.
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- The study analyzed 792 lung transplant surgeries to evaluate surgical complications and their effects on mortality and survival.
- Out of 769 patients reviewed, 32% experienced complications, leading to a significant increase in 30-day mortality rates among those patients.
- Key factors influencing complications included the type of transplant, patient age, and the necessity for extracorporeal support, which contributed to poorer long-term survival outcomes.