Mycobacterial β-carbonic anhydrases: Molecular biology, role in the pathogenesis of tuberculosis and inhibition studies.

Mycobacterium tuberculosis (Mtb), which causes tuberculosis (TB), is still a major global health problem. According to the World Health Organization (WHO), TB still causes more deaths worldwide than any other infectious agent. Drug-sensitive TB is treatable using first-line drugs; treatment of multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB requires second- and third-line drugs.

Mild aseptic lymphocyte-dominated vasculitis-associated lesion (ALVAL)-type reactions also present in patients with failed knee prostheses.

Aims: Metal particles detached from metal-on-metal hip prostheses (MoM-THA) have been shown to cause inflammation and destruction of tissues. To further explore this, we investigated the histopathology (aseptic lymphocyte-dominated vasculitis-associated lesions (ALVAL) score) and metal concentrations of the periprosthetic tissues obtained from patients who underwent revision knee arthroplasty. We also aimed to investigate whether accumulated metal debris was associated with ALVAL-type reactions in the synovium.

A Novel Approach to Using Spectral Imaging to Classify Dyes in Colored Fibers.

In the field of cultural heritage, applied dyes on textiles are studied to explore their great artistic and historic values. Dye analysis is essential and important to plan correct restoration, preservation and display strategy in museums and art galleries. However, most of the existing diagnostic technologies are destructive to the historical objects.

Direct pulmonary delivery of solubilized curcumin reduces severity of lethal pneumonia.

Acute respiratory distress syndrome (ARDS), the most severe form of acute lung injury, is associated with reduced lung compliance and hypoxemia. Curcumin exhibits potent anti-inflammatory properties but has poor solubility and rapid plasma clearance. To overcome these physiochemical limitations and uncover the full therapeutic potential of curcumin in lung inflammation, in this study we utilized a novel water-soluble curcumin formulation (CDC) and delivered it directly into the lungs of C57BL/6 mice inoculated with a lethal dose of ().

Histopathological patterns seen around failed metal-on-metal hip replacements: Cluster and latent class analysis of patterns of failure.

We aimed to establish latent subtypes of histopathological patterns in failed metal-on-metal hip replacements. Tissue samples of the synovia from the neocapsule were retrieved from 284 revised ASR (Articular Surface Replacement) hip replacements and analyzed histologically. Hierarchical cluster analysis and polytomous latent class analysis were performed to establish the underlying structure and relationships of the histological observations and to find similar cohorts of cases.