The topology of a chaotic attractor in the Kuramoto-Sivashinsky equation.

The Birman-Williams theorem gives a connection between the collection of unstable periodic orbits (UPOs) contained within a chaotic attractor and the topology of that attractor, for three-dimensional systems. In certain cases, the fractal dimension of a chaotic attractor in a partial differential equation (PDE) is less than three, even though that attractor is embedded within an infinite-dimensional space. Here, we study the Kuramoto-Sivashinsky PDE at the onset of chaos.

Understanding the role of perfectionism in contributing to internalizing symptoms in youth with juvenile idiopathic arthritis.

Objective: Youth with juvenile idiopathic arthritis (JIA) experience elevated rates of internalizing symptoms, although more research is required to understand this phenomenon. Perfectionism, a multidimensional personality trait that involves dimensions such as striving for flawlessness (self-oriented perfectionism) and feeling that others demand perfection (socially-prescribed perfectionism), is a well-known risk factor for internalizing symptoms that has received minimal attention in pediatric populations. Preregistered hypotheses explored the relationships between youth and parent perfectionism and symptoms of depression and anxiety in youth with JIA, as mediated by (a) youth/parent negative self-evaluations and (b) youth self-concealment.

Linking tumor immune infiltration to enhanced longevity in recurrence-free breast cancer.

Background: The infiltration of tumor-infiltrating B cells and plasma cells in early-stage breast cancer has been associated with a reduced risk of distant metastasis. However, the influence of B-cell tumor infiltration on overall patient survival remains unclear.

Materials And Methods: This study explored the relationship between an antitumor immune response, measured by a 14-gene B-cell/immunoglobulin (IGG) signature, and mortality risk in 9638 breast cancer patients across three datasets.

FAIRSCAPE: An Evolving AI-readiness Framework for Biomedical Research.

Motivation: Artificial intelligence (AI) applications require explainability (XAI) for FAIR, ethical deployment, whether in the clinic or in the laboratory. Richly descriptive XAI metadata representing how pre-model data were obtained, characterized, transformed, and distributed, should be available along with the data prior to training and application of AI models.

Results: The FAIRSCAPE framework generates, packages, and integrates critical pre-model XAI descriptive metadata, including deep provenance graphs and data dictionaries with feature validation on uploaded data, software, and computations, with special reference to biomedical datasets.

Heterozygous UBR5 variants result in a neurodevelopmental syndrome with developmental delay, autism, and intellectual disability.

E3 ubiquitin ligases have been linked to developmental diseases including autism, Angelman syndrome (UBE3A), and Johanson-Blizzard syndrome (JBS) (UBR1). Here, we report variants in the E3 ligase UBR5 in 29 individuals presenting with a neurodevelopmental syndrome that includes developmental delay, autism, intellectual disability, epilepsy, movement disorders, and/or genital anomalies. Their phenotype is distinct from JBS due to the absence of exocrine pancreatic insufficiency and the presence of autism, epilepsy, and, in some probands, a movement disorder.