Publications by authors named "J Pannequin"
Article Synopsis
- The study aims to improve the detection of cancer stem cells (CSCs) in non-small cell lung cancer (NSCLC) using specific glycan patterns, addressing challenges posed by current resistance mechanisms and relapses.* -
- Researchers compared a lectin-based method (MIX) for detecting CSCs with the traditional CD133 marker, finding that MIX enriched for more tumorigenic CSCs and showed stronger prognostic value for patient outcomes.* -
- The findings suggest that MIX may be a more effective CSC marker than CD133, potentially helping clinicians identify early-stage NSCLC patients at greater risk of relapse for better treatment planning.*
Upon parasitic helminth infection, activated intestinal tuft cells secrete interleukin-25 (IL-25), which initiates a type 2 immune response during which lamina propria type 2 innate lymphoid cells (ILC2s) produce IL-13. This causes epithelial remodeling, including tuft cell hyperplasia, the function of which is unknown. We identified a cholinergic effector function of tuft cells, which are the only epithelial cells that expressed choline acetyltransferase (ChAT).
View Article and Find Full Text PDFBackground: Cancer stem cells (CSCs) are at the origin of tumour initiation and progression in gastric adenocarcinoma (GC). However, markers of metastasis-initiating cells remain unidentified in GC. In this study, we characterized CD44 variants expressed in GC and evaluated the tumorigenic and metastatic properties of CD44v3+ cells and their clinical significance in GC patients.
View Article and Find Full Text PDFCancer stem cells play a crucial role in tumor initiation, metastasis, and resistance to treatment. Cellular heterogeneity and plasticity complicate the isolation of cancer stem cells. The impact of intra-tumor cellular heterogeneity using a label-free approach remains understudied in the context of treatment resistance.
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