Publications by authors named "J Pallud"
Background: Radiologically presumed diffuse lower-grade glioma (dLGG) are typically non or minimal enhancing tumors, with hyperintensity in T2w-images. The aim of this study was to test the clinical usefulness of deep learning (DL) in mutation prediction in patients with radiologically presumed dLGG.
Methods: Three hundred and fourteen patients were retrospectively recruited from 6 neurosurgical departments in Sweden, Norway, France, Austria, and the United States.
Article Synopsis
- A study examined the effectiveness of a watch-and-wait strategy versus standard postoperative treatment in patients with grade 3 gliomas after surgery, focusing on -mutant cases.
- An analysis of 106 patients over 12 years showed that those in the watch-and-wait group had better pre-surgery health metrics but similar long-term survival rates compared to those receiving adjuvant oncological treatment.
- The findings suggest that patients with selected grade 3 gliomas who undergo complete tumor removal can safely opt for a watch-and-wait approach without negatively impacting their survival outcomes.
Article Synopsis
- Grade 3 meningiomas are rare and linked to high morbidity and mortality, but the effects of surgical resection and radiation therapy on patient outcomes are still debated.
- A study was conducted on 65 patients with de novo anaplastic meningiomas, revealing a median progression-free survival of 23 months and an overall survival of 2 years, with certain treatments showing significant impact.
- The combination of gross-total resection and adjuvant radiotherapy improved progression-free survival, while tumor grade and age at diagnosis also affected outcomes.
Phenotypic and epigenetic heterogeneity in FGFR2-fused glial and glioneuronal tumours.
Neuropathol Appl Neurobiol
December 2024
Aims: FGFR-fused central nervous system (CNS) tumours are rare and are usually within the glioneuronal and neuronal tumours or the paediatric-type diffuse low-grade glioma spectrum. Among this spectrum, FGFR2 fusion has been documented in tumours classified by DNA-methylation profiling as polymorphous low-grade neuroepithelial tumours of the young (PLNTY), a recently described tumour type. However, FGFR2 fusions have also been reported in glioneuronal tumours, highlighting the overlapping diagnostic criteria and challenges.
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