Publications by authors named "J Paladino"
Article Synopsis
- - Dashboards in health systems help track and improve serious illness conversation (SIC) quality indicators, but the effectiveness and challenges of these dashboards are still not fully understood.
- - Interviews with palliative care leaders revealed that while dashboards can enhance data transparency and support clinician practice changes, they rely heavily on structured documentation that clinicians don't always use effectively.
- - Key challenges include ensuring the reliability of data, securing necessary resources for dashboard maintenance, and integrating patient-centered outcome measures, which may hinder the overall effectiveness of these tools in practice.
Article Synopsis
- People with early Alzheimer's disease (AD) are starting to use anti-amyloid monoclonal antibodies (mAbs) for treatment, but their views on risks and benefits are not well understood.
- * A study involving semi-structured interviews with 22 participants revealed that they gather information from various sources like advocacy groups, the internet, and healthcare providers to make treatment decisions.
- * Key themes identified in the study included: the desire for better understanding of the treatment, the hope for improved quality of life, and how personal and family factors shape their willingness to accept treatment despite its risks.*
The mammalian Brg1/Brm-associated factor (BAF) complexes are major regulators of nucleosomal remodeling that are commonly mutated in several cancers, including germinal center (GC)-derived B cell lymphomas. However, the specific roles of different BAF complexes in GC B cell biology are not well understood. Here we show that the AT-rich interaction domain 1a (Arid1a) containing canonical BAF (cBAF) complex is required for maintenance of GCs and high-affinity antibody responses.
View Article and Find Full Text PDFBackground: Delivering a diagnosis of Alzheimer's disease and related dementias (ADRD) can be challenging not just for patients and families, but also for clinicians. Our objective was to understand dementia specialty care clinicians' perspectives on their role in diagnosis and diagnostic disclosure in dementia.
Methods: Qualitative interviews with clinicians from a specialty tertiary dementia care center focused on practices, challenges, and opportunities addressing patient and caregiver needs in dementia.