Mixed-effects polygenic risk score Phenome-wide association study detects genetic correlation between colorectal cancer risk and phenotype data extracted from the electronic health record.

Many factors, including environmental and genetic variables, contribute to Colorectal Cancer (CRC) risk. Some of these risk factors may share underlying genetics with CRC. We investigated potential shared genetics by performing a Phenome-wide association study (PheWAS) with a multi-ancestry CRC polygenic risk score (PRS).

Ergodic seismic precursors and transfer learning for short term eruption forecasting at data scarce volcanoes.

Seismic data recorded before volcanic eruptions provides important clues for forecasting. However, limited monitoring histories and infrequent eruptions restrict the data available for training forecasting models. We propose a transfer machine learning approach that identifies eruption precursors-signals that consistently change before eruptions-across multiple volcanoes.

Reefs of Brachidontes exustus and Petaloconchus spp. as traps and sink for microplastics in tropical coastal areas.

Microplastics (MPs) are emerging contaminants in marine environments. This study quantified, chemically identified, and described MPs in reefs of Brachidontes exustus and Petaloconchus spp. on the tropical coast of Brazil.

Cost-savings and health impact of strategies for prevention of Respiratory Syncytial Virus with nirsevimab in Chile based on the integrated analysis of 2019-2023 national databases: A retrospective study.

Background: In the latter half of 2023, the northern hemisphere initiated the rollout of nirsevimab immunization strategies for infants, yielding promising early results. As Chile prepared for its 2024 strategy implementation, we retrospectively evaluated the potential cost-saving nature of various immunization strategies.

Methods: Leveraging comprehensive inpatient, outpatient, and sentinel programs data, we conduct a simulation-based retrospective analysis to evaluate the net cost savings of various immunization strategies based on nirsevimab.