A transcriptomic signature of X chromosome overdosage in Saudi Klinefelter syndrome induced pluripotent stem cells.

Objective: The transcriptional landscape of Klinefelter syndromeduring early embryogenesis remains elusive. This study aimed to evaluate the impact of X chromosome overdosage in 47,XXY males induced pluripotent stem cells (iPSCs) obtained from patients with different genomic backgrounds and ethnicities.

Design And Method: We derived and characterized 15 iPSC lines from four Saudi 47,XXY KS patients and one Saudi 46,XY male.

Status epilepticus. Can the incidence be reduced?

Objective: To identify high risk groups for the development of convulsive status epilepticus (CSE) in an attempt to decrease the incidence and to determine both the time to access to medical care and the use of prehospital treatment in an attempt to reduce the duration of seizing.

Methods: Retrospective study record analysis of all cases of CSE in children, at the King Abdul-Aziz University Hospital, Jeddah, Kingdom of Saudi Arabia from June 1997 to June 2000.

Results: During the study period there were 24 cases of CSE.