Publications by authors named "J P Viala"
Article Synopsis
- Familial Mediterranean fever (FMF) is a hereditary inflammatory disease commonly affecting digestion, but its digestive issues during attack-free periods have been under-researched.
- This study looked at 10 pediatric FMF patients who had endoscopy or colonoscopy and found common features such as the M694V mutation, chronic abdominal pain, iron deficiency, and growth retardation.
- Histological findings showed low-grade mucosal inflammation, indicating a unique intestinal profile that differs from typical inflammatory bowel diseases, suggesting these patients need specialized gastroenterological care.
During SARS-CoV-2 pandemic, the assessment of immune protection of people at risk of severe infection was an important goal. The appearance of VOCs (Variant of Concern) highlighted the limits of evaluating immune protection through the humoral response. While the humoral response partly loses its neutralizing activity, the anti-SARS-CoV-2 memory T cell response strongly cross protects against VOCs becoming an indispensable tool to assess immune protection.
View Article and Find Full Text PDFObjectives: Previous studies have shown rates of surgical resection of up to 41% in stricturing pediatric Crohn's disease (CD). In this retrospective multicenter study, our aims were to identify clinical risk factors and magnetic resonance enterography (MRE) features of small bowel strictures associated with surgery.
Methods: Pediatric patients with symptomatic stricturing small bowel CD (defined as obstructive symptoms or proximal dilatation on MRE) confirmed by MRE between 2010 and 2020 were recruited from 12 French tertiary hospitals.
Article Synopsis
- Infliximab (IFX) is evaluated as a second-line treatment for pediatric Crohn's disease (CD) patients who experience loss of response (LOR) or intolerance to adalimumab (ADA) after one year of therapy.
- A study involving 32 patients showed that 84.4% continued with IFX after 12 months, with 68.7% achieving corticosteroid-free clinical remission.
- Key finding indicates that absence of perianal disease at the start of IFX correlates with better remission outcomes, suggesting IFX is a viable option when ADA fails.
Gastrocolic fistulas are very rare in children and their association with Helicobacter pylori is poorly described. We present the case of a 10-year-old boy with a history of chronic abdominal pain, diarrhea, halitosis, and growth delay diagnosed with H. pylori-associated gastritis and gastrocolic fistula.
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