Publications by authors named "J P Valat"
Introduction: Sleeve gastrectomy is the most commonly performed bariatric operation globally. The main complication is GERD. In the medium term, it can increase the incidence of Barrett's esophagus (BE), which is a risk factor for esophageal adenocarcinoma.
View Article and Find Full Text PDFOne challenge faced by scientists from the alternative RNA splicing field is to decode the cooperative or antagonistic effects of splicing factors (SFs) to understand and eventually predict splicing outcomes on a genome-wide scale. In this manuscript, we introduce SplicingLore, an open-access database and web resource that help to fill this gap in a straightforward manner. The database contains a collection of RNA-sequencing-derived lists of alternative exons regulated by a total of 75 different SFs.
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- DDX5 and DDX17 are RNA helicases that play important roles in gene expression, particularly in regulating transcription and splicing, though their exact mechanisms are not fully known.
- Analysis of human cells lacking DDX5 and DDX17 showed significant disruptions in splicing and 3' end processing of RNA.
- The study suggests that DDX5 and DDX17 help form chromatin loops that connect specific gene regions to their promoters, influencing how RNA is spliced and processed.
Article Synopsis
- This study evaluates how French physicians manage and deliver information to patients with acute low back pain (LBP) and compares their practices to the COST B13 guidelines.
- It involved 528 physicians, analyzing their self-reported practices, knowledge of guidelines, and the impact of providing them with a summary of the recommendations.
- Results showed that while a majority of physicians were aware of the COST B13 guidelines and applied them to some extent, rheumatologists had more consistent practices than general practitioners.
Objectives: Despite the availability of practice guidelines for the management of knee osteoarthritis, inadequacies in practices of clinicians and patients have been found, leading to suboptimal outcomes. Literature has shown that simply disseminating management recommendations does not lead to adherence. Research suggests that barriers to use should be identified and addressed to improve adherence.
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