Publications by authors named "J P Toutain"
Tumor hypoxia significantly limits the effectiveness of radiotherapy, as oxygen is crucial for producing cancer-killing reactive oxygen species. To address this, we synthesized nanosized faujasite (PBS-Na-FAU) zeolite crystals using clinical-grade phosphate-buffered saline (PBS) as the solvent, ensuring preserved crystallinity, microporous volume, and colloidal stability. The zeolite nanocrystals showed enhanced safety profiles and , and studies showed no apparent toxicity to animals.
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- Radiotherapy for brain tumors can cause cognitive impairments, and this study explores how deformation-based morphometry (DBM) using Jacobian determinants can help detect vulnerable areas in the brain after radiation exposure in an animal model.
- Rats underwent whole-brain irradiation (WBI, 30 Gy), and a series of MRI tests over six months assessed both macroscopic and microscopic brain changes, focusing on cerebral blood volume and diffusion metrics.
- The results indicated specific brain regions, such as the corpus callosum and cortex, displayed both transient and lasting structural changes due to radiation, highlighting DBM's potential for identifying at-risk brain areas in future patient treatments.
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- * In a study using PET imaging on glioblastoma models, the injected [Cu]-FAU nanocrystals accumulated rapidly in tumor areas while avoiding healthy brain tissue, with uptake kinetics varying between different glioblastoma models (U87-MG and U251-MG).
- * The research confirmed the presence of zeolite nanocrystals in the tumors and demonstrated the potential of this radiolabeling technique for precise PET tracking, supporting the use of zeolite nanocr
Article Synopsis
- The study investigates how different types of radiation therapy (X-ray vs. proton therapy) affect various circulating leucocyte (white blood cell) subpopulations in mice, particularly in the context of tumor tolerance.
- Findings indicate that X-ray radiation causes lymphopenia (a reduction in lymphocyte counts), while proton therapy does not significantly impact lymphoid subpopulations; however, there is an increase in neutrophil counts with proton exposure.
- The research highlights the complex relationship between radiation type, volume irradiated, dose rate, and their effects on immune cell populations, suggesting direct lymphocyte-killing effects are only a minor contributor to radiation-induced lymphopenia.
Article Synopsis
- - The study investigates the relationship between hypoxia and RASSF1A/Hippo signaling in non-small cell lung cancer (NSCLC) and its brain metastases, confirming that both are hypoxic with a specific marker, CAIX.
- - Severe hypoxia activates the YAP protein in bronchial epithelial cells, which promotes amoeboid migration and brain metastasis formation, while also showing that NDR2 kinase is overactive in metastatic NSCLC compared to localized cases.
- - The findings suggest that NDR2 could serve as a valuable biomarker to assess the risk of metastasis in NSCLC patients, as its expression can be routinely measured via immunohistochemistry on tumor samples.