A Porcine-Derived Heme Iron Powder Restores Hemoglobin in Anemic Rats.

Background/objectives: Iron-fortified foods reduce the incidence of iron deficiency anemia. However, the nutritional efficacy of heme iron fortificants is unclear.

Methods: In this study, we determined the hemoglobin regeneration efficiency (HRE) of a porcine-derived heme iron powder (HIP), treating anemic rats (hemoglobin (Hb) 3-6 g/dL) with 14-day repletion diets fortified with four different concentrations (12, 24, 36, or 48 mg iron/kg diets) of HIP or a control diet ("no added iron"); = 9-12/group.

Advancements in framework materials for enhanced energy harvesting.

Energy harvesting, the process of capturing ambient energy from various sources and converting it into usable electrical power, has attracted a lot of attention due to its potential to provide long-term and self-sufficient energy solutions. This comprehensive review thoroughly explores the use of metal-organic frameworks (MOFs) and covalent organic frameworks (COFs) for energy harvesting by piezoelectric and triboelectric nanogenerators (PENGs and TENGs). It begins by classifying and outlining the structural diversity of MOFs and COFs, which is key to understanding their importance in energy applications.

Contribution of the infection ecosystem and biogeography to antibiotic failure in vivo.

The acquisition of antibiotic resistance in bacteria, though a deeply concerning international issue, is reasonably well-understood at a mechanistic level. Less well-understood is why bacteria that are sensitive in vitro to well-established and widely-used antibiotics sometimes fail to respond to these agents in vivo. This is a particularly common problem in chronic, polymicrobial infection scenarios.

Overexpression of Phytoglobin1 in Rice Leads to Enhanced Nitrogen Use Efficiency via Modulation of Nitric Oxide.

Nitric oxide (NO) is one of the byproducts of nitrogen metabolism. Excess amount of NO is scavenged by phytoglobins. The role of phytoglobin mediated NO homoeostasis in modulation of nitrate transporters was investigated using NO scavenger cPTIO, phytoglobin overexpressing rice and Arabidopsis.

Probing the Effects of Chirality on Self-Assembling Peptides: Hydrogel Formation, Degradation, Antigen Release, and Adjuvancy.

Introduction: Multidomain peptides (MDPs) are amino acid sequences that self-assemble to form supramolecular hydrogels under physiological conditions that have shown promise for a number of biomedical applications. K(SL)K ("K"), a widely studied MDP, has demonstrated the ability to enhance the humoral immune response to co-delivered antigen. Herein, we sought to explore the in vitro and in vivo properties of a peptide with the same sequence but opposite chirality (D-K) since peptides composed of D-amino acids are resistant to protease degradation and potentially more immunostimulatory than their canonical counterparts.