Publications by authors named "J P Soulillou"
Article Synopsis
- Recent research tested a new treatment called LIS1, derived from genetically modified pigs, to see if it could safely be used in kidney transplant patients instead of traditional rabbit-derived antithymocyte globulins (ATGs).
- The study showed that LIS1 effectively depleted T cells without causing major side effects, such as cytokine release syndrome, and was well tolerated by patients.
- Results indicated that LIS1 has a long half-life and allows for quick recovery of lymphocyte counts, suggesting it could be a promising alternative for transplant immunosuppression.
Calcification of surgical aortic bioprostheses and its impact on clinical outcome.
Guillaume Guimbretière Thomas Sénage Anne-Sophie Boureau Jean-Charles Roos Quentin Bernard Jean-Paul Soulillou
Eur Heart J Cardiovasc Imaging
August 2024
Article Synopsis
- Aortic valve calcification (AVC) was studied in patients with bioprosthetic valves to assess its impact on patient prognosis.
- In a study of 361 patients who had valve replacements, AVC was found to be significantly higher in those with structural valve degeneration (SVD).
- The results indicate that AVC greater than 100 Agatston units is correlated with worse health outcomes and increased risk of mortality and cardiovascular events, making CT scans a valuable tool for evaluation.
Article Synopsis
- Polyclonal rabbit antithymocyte globulins (ATGs) used in organ transplants can cause unwanted inflammation, while LIS1, a new generation of antilymphocyte globulins derived from genetically modified pigs, aims to reduce these risks.
- A phase 1 study tested LIS1 in kidney transplant patients to assess its safety, T cell depletion effects, and pharmacokinetics.
- Results indicated that LIS1 was well tolerated, effectively depleted T cells in certain dosage groups, and did not provoke severe side effects or the formation of antidrug antibodies.
Structural valve deterioration (SVD) of bioprosthetic heart valves (BHVs) has great clinical and economic consequences. Notably, immunity against BHVs plays a major role in SVD, especially when implanted in young and middle-aged patients. However, the complex pathogenesis of SVD remains to be fully characterized, and analyses of commercial BHVs in standardized-preclinical settings are needed for further advancement.
View Article and Find Full Text PDFMultiple sclerosis is an autoimmune disease of the central nervous system. Yet, the autoimmune targets are still undefined. The extracellular e1 sequence of KCNJ10, the inwardly rectifying potassium channel 4.
View Article and Find Full Text PDF