Variability of intestinal colonization with third-generation cephalosporin-resistant Enterobacteriaceae and antibiotic use in intensive care units.

Objectives: Healthcare-associated infections due to third-generation cephalosporin-resistant Enterobacteriaceae (CRE) have become a major public health threat, especially in intensive care units (ICUs). We assessed and compared β-lactam use, the prevalence of colonization with CRE at admission and the incidence of CRE acquisition across ICUs.

Patients And Methods: A cohort study was conducted in 10 ICUs of the Paris (France) metropolitan area between November 2005 and February 2006.

Factors associated with hospital mortality in community-acquired legionellosis in France.

The aims of this study were to describe the clinical, biological and radiological features of community-acquired (CA) Legionnaires' disease (LD) and identify the predictors of mortality in hospitalised patients. Demographic data, risk factors, clinical and biological features, medical management, complications, and outcome from 540 hospitalised patients with confirmed CA LD were prospectively recorded. 8.

[Interest of real-time PCR Xpert MRSA/SA on GeneXpert(®) DX System in the investigation of staphylococcal bacteremia].

Aim Of The Study: Recently, a rapid, fully automated real-time PCR test has become available for detection of Staphylococcus aureus in positive blood cultures, Xpert MRSA/SA blood culture. This study was defined to evaluate the use of this product in our hospital setting to assist in optimizing antibiotic treatment.

Materials And Methods: Over a period of 18months (from February 2008 to July 2009), 51 positive blood cultures were examined for Staphylococcus using the Xpert MRSA/SA assay on the GeneXpert(®) System.

Epidemiology, management, and risk factors for death of invasive Candida infections in critical care: a multicenter, prospective, observational study in France (2005-2006).

Objective: To describe the evolving epidemiology, management, and risk factors for death of invasive Candida infections in intensive care units (ICUs).

Design: Prospective, observational, national, multicenter study.

Setting: One hundred eighty ICUs in France.

[Invasive candidiasis in ICU: analysis of antifungal treatments in the French study AmarCand].

Objective: Comparison of treatments initiated during invasive candidiasis in intensive care units with current French guidelines.

Study Design: Prospective, observational, French multicenter study (October 2005-May 2006).

Patients And Methods: Selection of patients with Candida species identification and in vitro antifungal susceptibility determination.