Publications by authors named "J P Shelley"
Article Synopsis
- Researchers are focused on creating new ionizable lipids for lipid nanoparticles (LNPs), essential for drug delivery systems.
- A new computational method has been developed to predict the apparent p value of these lipids when formulated in LNPs.
- This method was tested on lipid formulations in COVID-19 vaccines (COMIRNATY, Spikevax) and a siRNA therapy (Onpattro), including a variant called Lipid A used in COMIRNATY.
This note details the first formal report of a spinal deformation in whale sharks, Rhincodon typus. An individual whale shark with suspected kypholordoscoliosis was observed at Ewing Bank in the Gulf of Mexico during aggregation events in 2010 and 2013. Despite the significant deformity, the shark was observed feeding on fish eggs at the surface during both encounters.
View Article and Find Full Text PDFSince 2020 wastewater-based surveillance has quickly been established as an effective and cost-efficient tool for monitoring public health. In this Making Waves article, we argue that these programs must be grounded in principles of justice to achieve global water and health equity. Ethics initiatives to date have focused primarily on privacy, legality, and institutionalised research reviews, often, if not exclusively, in North America and Western Europe.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates idiopathic short stature (ISS) in children, hypothesizing that a polygenic score for height (PGS) may reveal an underlying heritable predisposition to shorter stature.
- Out of 534 pediatric participants, 22.1% were diagnosed with ISS, showing slightly lower PGS values compared to those with familial short stature but significantly lower than those with underlying health issues, indicating a greater genetic predisposition to short stature in ISS cases.
- The findings suggest PGS not only differentiates between ISS and short stature due to diseases but also enhances predictive models for adult height, highlighting its potential clinical usefulness in assessing children with unexplained short stature.
Importance: Leveraging real-world clinical biobanks to investigate the associations between genetic and environmental risk factors for mental illness may help direct clinical screening efforts and evaluate the portability of polygenic scores across environmental contexts.
Objective: To examine the associations between sexual trauma, polygenic liability to mental health outcomes, and clinical diagnoses of schizophrenia, bipolar disorder, and major depressive disorder in a clinical biobank setting.
Design, Setting, And Participants: This genetic association study was conducted using clinical and genotyping data from 96 002 participants across hospital-linked biobanks located at Vanderbilt University Medical Center (VUMC), Nashville, Tennessee (including 58 262 individuals with high genetic similarity to the 1000 Genomes Project [1KG] Northern European from Utah reference population [1KG-EU-clustered] and 11 047 with high genetic similarity to the 1KG African-ancestry reference population of Yoruba in Ibadan, Nigeria [1KG-YRI-clustered]), and Mass General Brigham (MGB), Boston, Massachusetts (26 693 individuals with high genetic similarity to the combined European-ancestry superpopulation [1KG-EU-clustered]).