Publications by authors named "J P Schlumbohm"

Alcohol use disorders (AUDs) are prevalent, and are characterized by binge-like drinking, defined by patterns of focused drinking where dosages ingested in 2-4 ​h reach intoxicating blood alcohol levels (BALs). Current medications are few and compliance with the relatively rare prescribed usage is low. Hence, novel and more effective medications are needed.

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Article Synopsis
  • Chronic alcohol exposure can change how glucocorticoid receptors (GR) function in certain brain areas, leading to increased binge drinking problems, particularly in specially bred mice that tend to consume more alcohol.
  • In experiments, blocking GR with specific compounds led to a significant decrease in binge drinking and blood alcohol concentrations (BECs) in HDID-1 mice, but did not affect consumption in HS/NPT mice, indicating potential differences in GR sensitivity due to selective breeding.
  • Despite finding that GR antagonism did not intensify the aversive reactions to alcohol in conditioned taste or place aversion tests, the results highlight the complex relationship between GR function and alcohol intake behaviors, warranting further investigation into selective
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Two independent lines of High Drinking in the Dark (HDID-1, HDID-2) mice have been bred to reach high blood alcohol levels after a short period of binge-like ethanol drinking. Male mice of both lines were shown to have reduced sensitivity to develop a taste aversion to a novel flavor conditioned by ethanol injections as compared with their unselected HS/NPT founder stock. We have subsequently developed inbred variants of each line.

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Despite acceptance that risk for alcohol-use disorder (AUD) has a large genetic component, the identification of genes underlying various components of risk for AUD has been hampered in humans, in part by the heterogeneity of expression of the phenotype. One aspect of AUD is physical dependence. Alcohol withdrawal is a serious consequence of alcohol dependence with multiple symptoms, many of which are seen in multiple species, and can be experienced over a wide-ranging time course.

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Background: There is a serious public health need for better understanding of alcohol use disorder disease mechanisms and for improved treatments. At this writing, only three drugs are approved by the Food and Drug Administration as medications to treat alcohol use disorders - disulfiram, naltrexone, and acamprosate. Binge drinking is a form of abusive alcohol drinking defined by the NIAAA as a drinking to blood alcohol levels (BALs)>0.

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