Publications by authors named "J P Sapp"
Background: Cardiopulmonary bypass (CPB) causes systemic inflammation during pediatric cardiac surgery, which can contribute to post-operative organ dysfunction and prolonged recovery. This study aims to identify key inflammatory mediators related to this clinically significant immunologic response.
Methods: Pediatric patients were enrolled in a single-arm prospective clinical study (NCT05154864) and received standard cardiac operation, CPB and subzero-balance ultrafiltration.
Background: The long-term effects of catheter ablation (CA) compared with medical therapy on cardiovascular outcomes for atrial fibrillation (AF) remain undetermined.
Objective: Using a population-based cohort, we sought to determine what the association between CA and medical therapy was on these outcomes.
Methods: By use of Alberta administrative data, patients with AF as the primary diagnosis during hospitalization, emergency department visit, or physician visit were included between October 1, 2008, and March 31, 2018.
-related Proteus syndrome is an ultra-rare mosaic overgrowth disorder with tumour predisposition. We conducted a systematic review to determine the range and characteristics of these tumours. A systematic review was conducted to identify clinical reports and clinical series of Proteus syndrome published between 1983 and 2023.
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- There is a lack of Canadian studies analyzing the costs of catheter ablation (CA) for atrial fibrillation (AF) using patient-specific data; this study aims to fill that gap.
- A cost analysis was conducted on AF patients in Nova Scotia, comparing health care costs 2 years before and after CA, highlighting a significant decrease in hospitalizations and ER visits post-ablation.
- Although the immediate costs of the treatment were high, the overall reduction in health care usage suggests that CA could be a cost-effective solution for AF treatment in the long run.
Background: Patients with ventricular tachycardia and ischemic cardiomyopathy are at high risk for adverse outcomes. Catheter ablation is commonly used when antiarrhythmic drugs do not suppress ventricular tachycardia. Whether catheter ablation is more effective than antiarrhythmic drugs as a first-line therapy in patients with ventricular tachycardia is uncertain.
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