Ophthalmologic Manifestations in Autism Spectrum Disorder.

Objectives: The purpose of this study was to describe the ophthalmologic manifestations found in patients with autism spectrum disorder (ASD) and to assess their prevalence in the different types of ASD.

Materials And Methods: This prospective observational study included 344 patients with ASD seen over a period of 8.5 years.

No association between the use of Bti for mosquito control and the dynamics of non-target aquatic invertebrates in French coastal and continental wetlands.

The environmental safety of Bacillus thuringiensis subsp. israelensis (Bti) is still controversial, mainly because most of the previous field studies on its undesired effects were spatially limited and did not address the relationship between community similarity and application time and frequency. No general statement can therefore be drawn on the usage conditions of Bti that insure protection of non-target organisms.

A new oral formulation of tiapride (drops): pharmacokinetic profile and therapeutic applications.

Tiapride is a substituted benzamide widely used in the management of agitation and aggressiveness in the elderly. The development of an oral solution is of particular interest in geriatric medicine and in patients with difficulties swallowing solid formulations. The bioequivalence between a sweetened, flavoured oral drop and tablet forms of tiapride was investigated in a crossover design in 18 healthy male volunteers after a 100mg single-dose administration of each formulation.

Variations in schedules of ifosfamide administration: a better understanding of its implications on pharmacokinetics through a randomized cross-over study.

Purpose: The metabolism of ifosfamide is a delicate balance between a minor activation pathway (4-hydroxylation) and a mainly toxification pathway (N-dechloroethylation), and there remains uncertainty as to the optimal intravenous schedule.

Methods: This study assesses ifosfamide pharmacokinetics (PK) according to two standard schedules. Using a 1:1 randomized trial design, we prospectively evaluated ifosfamide PK on two consecutive cycles of 3 g/m2/day for 3 days (9 g/m2/cycle) given in one of two schedules either by continuous infusion (CI) or short (3 h) infusion.