Bigels in which the cationic polymer -chitosan- is combined with an anionic polymer -karaya gum, pectin or xanthan gum- were prepared. These polymers, thanks to the attraction of their charged surface groups, are liable to form a polyelectrolyte complex that would modify the characteristics of the bigel. The obtained bigels were subsequently freeze-dried and tested to study their behavior against different conditions occurring in the vaginal environment.
View Article and Find Full Text PDFThis paper deals with the problem of robust regulation of a Planar Vertical Takeoff and Landing (PVTOL) aircraft affected by crosswind disturbances. The proposed approach simultaneously exploits the advantages of passivity-based control and the integral sliding mode (ISM) control technique. We demonstrate that the passivity-based controller accomplishes the PVTOL regulation within a guaranteed stability region.
View Article and Find Full Text PDFAims: To examine the associations between and polymorphisms, plasma oxycodone and metabolite concentrations, and oxycodone response (dose, pain scores, and adverse effects) in people with pain from advanced cancer.
Patients & Methods: This multi-center prospective cohort study included clinical data, questionnaires (pain and adverse effects), and blood (pharmacokinetics, DNA). Negative binomial regression and logistic regression were used.