Publications by authors named "J P Rovers"
Background: The World Health Organization (WHO) defines vaccine hesitancy as "a delay in acceptance or refusal of vaccines despite availability of vaccination services". Vaccine hesitancy has also been declared a top threat to global health. Some employers imposed vaccine mandates during the Covid-19 pandemic resulting in health care employees resigning or being fired rather than receive a vaccine.
View Article and Find Full Text PDFPD-1 checkpoint inhibition has revolutionized the care of cancer. A small portion of patients with stage IV cancer achieve durable control. But, early progression is common and dramatic control is achieved for only a minority.
View Article and Find Full Text PDFReliable predictors for electroconvulsive therapy (ECT) effectiveness would allow a more precise and personalized approach for the treatment of major depressive disorder (MDD). Prediction models were created using a priori selected clinical variables based on previous meta-analyses. Multivariable linear regression analysis was used, applying backwards selection to determine predictor variables while allowing non-linear relations, to develop a prediction model for depression outcome post-ECT (and logistic regression for remission and response as secondary outcome measures).
View Article and Find Full Text PDFArticle Synopsis
- The study compares two strategies for managing high blood pressure in patients with ischaemic strokes who are eligible for intravenous thrombolysis: an active blood-pressure-lowering strategy and a conservative, non-lowering approach.
- Conducted across 37 Dutch stroke centers, it involved eligible adults with elevated blood pressure and aimed to assess functional outcomes at 90 days, alongside secondary measures like complications and treatment timing.
- The trial started in January 2015 but was prematurely halted due to low patient enrollment and lack of funding.
The effect of administering preprocedural VITamin K on the international normalized ratio in patients anticoagulated with ACEnocoumarol (VITKACE-study): a prospective cohort study.
J Thromb Haemost
July 2024
Background: The effect of the vitamin K antagonist acenocoumarol on coagulation needs to be reversed when patients undergo an invasive procedure with considerable bleeding risk. A strategy to achieve this is by administering oral vitamin K before a procedure while continuing acenocoumarol.
Objectives: To assess the effect on periprocedural international normalized ratio (INR) values and safety using oral vitamin K as anticoagulant reversal method.