Publications by authors named "J P Rigalli"
The insulin-like growth factor-2 mRNA-binding protein 1 (IGF2BP1), a member of a conserved family of single-stranded RNA-binding proteins (IGF2BP1-3), is expressed in a broad range of fetal tissues, placenta and more than sixteen cancer types but only in a limited number of normal adult tissues. IGF2BP1is required for the transport from nucleus to cytoplasm of certain mRNAs that play essential roles in embryogenesis, carcinogenesis, and multidrug resistance (MDR), by affecting their stability, translation, or localization. The purpose of this review is to gather and present information on MDR mechanisms in cancer and the significance of IGF2BP1 in this context.
View Article and Find Full Text PDFDrug efflux transporters of the ATP-binding-cassette superfamily play a major role in the availability and concentration of drugs at their site of action. ABCC2 (MRP2) and ABCG2 (BCRP) are among the most important drug transporters that determine the pharmacokinetics of many drugs and whose overexpression is associated with cancer chemoresistance. ABCC2 and ABCG2 expression is frequently altered during treatment, thus influencing efficacy and toxicity.
View Article and Find Full Text PDFDrug-metabolizing enzymes (DMEs) and transporters play a major role in drug efficacy and safety. They are regulated at multiple levels and by multiple factors. Estimating their expression and activity could contribute to predicting drug pharmacokinetics and their regulation by drugs or pathophysiological situations.
View Article and Find Full Text PDFCancer multidrug resistance (MDR) is one of the main mechanisms contributing to therapy failure and mortality. Overexpression of drug transporters of the ABC family (ATP-binding cassette) is a major cause of MDR. Extracellular vesicles (EVs) are nanoparticles released by most cells of the organism involved in cell-cell communication.
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- Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in PKD1 or PKD2, leading to kidney cyst formation and progressive disease.
- Research suggests that extracellular vesicles (EVs) released from PKD1 knockout cells may promote cyst growth by affecting nearby cells through purinergic signaling.
- A study demonstrated that EVs from PKD1 deficient distal convoluted tubule cells increased ATP release and activated pathways related to cell proliferation in the inner medullary collecting duct, resulting in larger cysts.