Publications by authors named "J P Reynaud"
Proposing a Methodology for Axon-Centric Analysis of IOP-Induced Mechanical Insult.
Invest Ophthalmol Vis Sci
November 2024
Article Synopsis
- The study investigates how intraocular pressure (IOP) affects the mechanical damage to retinal ganglion cell axons, focusing on the specifics of axonal stretch and compression rather than just tissue-level impacts.
- Using optical coherence tomography (OCT) scans and histological images, the researchers reconstructed the volume occupied by axons and measured strains at different IOP levels to understand the mechanical insults on these axons.
- The findings reveal that axons in different regions experience various types of mechanical strain, suggesting that understanding these specific insults may help in connecting IOP changes with glaucoma development, and more research with larger groups is needed.
Objectives: Bronchopulmonary dysplasia (BPD) is a chronic lung disease that affects premature babies and contributes to their morbidity. French BPD guidelines suggest the use of intravenous methylprednisolone pulses (IVMP) for those who require respiratory support (RS) following 36 weeks postmenstrual age (PMA). However, there is scant data on the efficacy and tolerance for this indication.
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- The study aims to evaluate how effectively the thickness of different macular retinal layers can differentiate glaucomatous eyes and glaucoma suspects from healthy eyes using optical coherence tomography (OCT).
- The findings reveal that the nerve fiber layer (NFL) and ganglion cell layer (GCL) have the best diagnostic accuracy, with the ganglion cell complex (GCC) performing similarly, while the inner plexiform layer (IPL) is less effective. The combination of NFL or GCL yields the highest sensitivity and overall diagnostic performance.
- The results underscore the necessity of assessing individual retinal layers rather than relying solely on combined metrics, as the best-performing layers can vary based on the specific area of the retina
Retrolaminar Demyelination of Structurally Intact Axons in Nonhuman Primate Experimental Glaucoma.
Invest Ophthalmol Vis Sci
February 2024
Purpose: To determine if structurally intact, retrolaminar optic nerve (RON) axons are demyelinated in nonhuman primate (NHP) experimental glaucoma (EG).
Methods: Unilateral EG NHPs (n = 3) were perfusion fixed, EG and control eyes were enucleated, and foveal Bruch's membrane opening (FoBMO) 30° sectoral axon counts were estimated. Optic nerve heads were trephined; serial vibratome sections (VSs) were imaged and colocalized to a fundus photograph establishing their FoBMO location.
Land artificialization is a serious problem of civilization. Urban planning and natural risk management are aimed to improve it. In France, these practices operate the Local Land Plans (PLU - Plan Local d'Urbanisme) and the Natural risk prevention plans (PPRn - Plan de Prévention des Risques naturels) containing land use rules.
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