Publications by authors named "J P Randazzo"
Background: To spare important anatomical structures from damage during treatment of cystic odontogenic lesions, decompression has become a conservative alternative to enucleation. Marsupialization, in combination with the use of a custom-made decompression prosthesis, is an effective method of inducing reduction and bony infill of cystic lesions of the jaw.
Methods: In this case series and review of the literature, we describe three patients with odontogenic cysts of the mandible who were treated with custom-made decompression obturator prostheses (DOP) at the Memorial Sloan Kettering Cancer Center Dental Service.
Objective: The objective of this study was to satisfy the US FDA's Center for Devices and Radiological Health regarding the safety of targeted osmotic lysis (TOL), a novel treatment for advanced carcinomas, in Beagle dogs.
Methods: 12 intact Beagle dogs, 6 males and 6 females, were divided into 2 treatment groups of 6, each receiving 3 TOL cycles. For each 6-day cycle, digoxin was administered orally at 0.
Background: One of the challenges to using some flavor chemicals in aerosol products is the lack of route of administration specific toxicology data.
Methods: Flavor chemicals (88) were divided into four different flavor mixtures based upon chemical compatibility and evaluated in 2-week dose-range-finding and subsequent 90-day nose-only rodent inhalation studies (OECD 413 and GLP compliant). Sprague-Dawley rats were exposed to vehicle control or one of three increasing concentrations of each flavor mixture.
Article Synopsis
- - Maxillary reconstruction is complicated due to 3D surgical sites and various tissue deficiencies, but advancements in virtual surgical planning (VSP) have improved the accuracy and efficiency of the process, allowing for better bony reconstructions and immediate dental implant placements (IDIP).
- - The study developed a new workflow that combines VSP, 3-D printed plates, and IDIP, reviewing patients from 2017-2022 who received osseous maxillary reconstruction using fibula flaps.
- - Results showed high success with only one dental implant failure and manageable complications, allowing most patients to obtain stable dental prostheses and ensuring no delays in their cancer treatment.