Publications by authors named "J P Ramos"
Patients diagnosed with metastatic colorectal cancer (mCRC) have a poor prognosis with survival ranging 2-3 years. The prevalence of human epidermal growth factor receptor 2 (HER2) amplification is approximately 3-4% in mCRC and increases up to 8% in patients with // wild-type (WT) CRC tumors. Tucatinib is a highly selective HER2-directed tyrosine kinase inhibitor that, in combination with trastuzumab, has demonstrated clinically meaningful activity in patients with chemotherapy-refractory, HER2-positive (HER2+), WT mCRC in the MOUNTAINEER trial.
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- The cystatin superfamily is vital for inhibiting cysteine proteases, which are involved in important biological functions like seed development and disease resistance in plants, and tumor progression in humans.
- A novel rice-derived chimeric legumain inhibitor was evaluated through simulations and laboratory tests, showing strong stability and affinity for the legumain enzyme.
- The study indicates that the chimeric Oryzacystatin I mutant could be a valuable candidate for developing new cancer treatments due to its effectiveness in reducing tumor cell migration and viability.
Febrile neutropenia is a major complication of the treatment of patients with hematologic diseases. Recent epidemiologic changes, with an increase in infection caused by drug-resistant bacteria, represent a major challenge for the proper management of febrile neutropenia. The impact of these changes in the epidemiology of infection may vary according to the region.
View Article and Find Full Text PDFHydrocephalus is the disruption of cerebral spinal fluid homeostasis, representing a common neurosurgical illness. Up to 10% have no identifiable cause, with fourth ventricle outflow obstruction (FVOO) being an extremely rare subtype. A 31-year-old male with a history of idiopathic hydrocephalus for over 10 years with the need for a ventriculoperitoneal shunt had shown progressively enlarged tetraventricular ventriculomegaly.
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- Coastal urbanization harms marine ecosystems, leading to habitat loss and pollution, which affects seabird species like Cory's and Scopoli's shearwaters in the Northeast Atlantic and Mediterranean.
- This study compares the fatty acid profiles and foraging patterns of these shearwaters, predicting that Scopoli's shearwaters will have lower diet quality with specific fatty acid markers linked to the Mediterranean's environmental challenges.
- While findings showed Scopoli's shearwaters had higher levels of some fatty acids associated with pollution, they also showed increased ω-3 fatty acid concentrations, suggesting a complex interaction of prey availability and environmental adaptations in their feeding ecology.