T cell immune evasion by SARS-CoV-2 JN.1 escapees targeting two cytotoxic T cell epitope hotspots.

Although antibody escape is observed in emerging severe acute respiratory syndrome coronavirus 2 variants, T cell escape, especially after the global circulation of BA.2.86/JN.

Boosting Natural Killer Cells' Immunotherapy with Amoxicillin-Loaded Liposomes.

Natural killer (NK) cell immunotherapy is a significant category in tumor therapy due to its potent tumor-killing and immunomodulatory effects. This research delves into exploring the mechanisms underlying the ability of amoxicillin to boost NK cell cytotoxicity in NK cell immunotherapy. Amoxicillin significantly enhances the cytotoxic activity of NK-92MI cells against MCF-7 cells by triggering the initiation of a cytolytic program in target cell-deficient NK-92MI cells and augmenting the degranulation level of NK-92MI cells in the presence of target cells.

Ocean wave-driven covalent organic framework/ZnO heterostructure composites for piezocatalytic uranium extraction from seawater.

Piezoelectric catalysis possesses the potential to convert ocean wave energy into and holds broad prospects for extracting uranium from seawater. Herein, the Z-type ZnO@COF heterostructure composite with excellent piezoelectric properties was synthesized through in situ growth of covalent organic frameworks (COFs) on the surface of ZnO and used for efficient uranium extraction. The designed COFs shell enables ZnO with stability, abundant active sites and high-speed electron transport channels.

Small pulmonary nodule localization techniques in the era of lung cancer screening: a narrative review.

The widespread adoption of high-resolution computed tomography (CT) screening has led to increased detection of small pulmonary nodules, necessitating accurate localization techniques for surgical resection. This review examines the evolution, efficacy, and safety of various localization methods for small pulmonary nodules. Studies focusing on localization techniques for pulmonary nodules ≤30 mm in diameter were included, with emphasis on technical success rates and complication profiles.

Disrupted Cross-Scale Network Associated With Cognitive-Emotional Disorders in Sudden Sensorineural Hearing Loss.

Background: Sudden sensorineural hearing loss (SSNHL) is associated with abnormal changes in the brain's central nervous system. Previous studies on the brain networks of SSNHL have primarily focused on functional connectivity within the brain. However, in addition to functional connectivity, structural connectivity also plays a crucial role in brain networks.