Publications by authors named "J P O'Neill"
Background: Change in the oxygen consumption (VO) at the ventilatory anaerobic threshold (VAT) is an important outcome in research studies of children with congenital heart disease (CHD). The range of values reported by different raters for any given VAT is needed to contextualize a change in VAT in intervention studies.
Methods: Sixty maximal cardiopulmonary exercise tests (CPET) for CHD patients 8-21 years old were independently reviewed by six exercise physiologists and four pediatric cardiologists.
Daily rhythms in the rate and specificity of protein synthesis occur in most mammalian cells through an interaction between cell-autonomous circadian regulation and daily cycles of systemic cues. However, the overall protein content of a typical cell changes little over 24 h. For most proteins, translation appears to be coordinated with protein degradation, producing phases of proteomic renewal that maximize energy efficiency while broadly maintaining proteostasis across the solar cycle.
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- * Among 86 patients screened, 8% tested positive for ATTR-CM, indicating a potential underdiagnosis of this condition in heart failure patients.
- * DPD scintigraphy-positive patients were typically older males with more significant heart changes compared to those who tested negative, highlighting the importance of screening in this cohort.
Aims: To explore the experiences, and perceptions of nurses who are told to withhold clinical information from children diagnosed with serious illnesses.
Design: An interpretative qualitative phenomenological design was used for the study. Sampling was purposive and data were collected using semi-structured interviews from nurses working in a paediatric setting within the preceding 5 years.