Optimized inverse kinematics modeling and joint angle prediction for six-degree-of-freedom anthropomorphic robots with Explainable AI.

Inverse kinematics, crucial in robotics, involves computing joint configurations to achieve specific end-effector positions and orientations. This task is particularly complex for six-degree-of-freedom (six-DoF) anthropomorphic robots due to complicated mathematical equations, nonlinear behaviours, multiple valid solutions, physical constraints, non-generalizability and computational demands. The primary contribution of this work is to address the complex inverse kinematics problem for six-DoF anthropomorphic robots through the systematic exploration of AI models.

Optogenetic elevation of postsynaptic cGMP in the hippocampal dentate gyrus enhances LTP and modifies mouse behaviors.

A major intracellular messenger implicated in synaptic plasticity and cognitive functions both in health and disease is cyclic GMP (cGMP). Utilizing a photoactivatable guanylyl cyclase (BlgC) actuator to increase cGMP in dentate granule neurons of the hippocampus by light, we studied the effects of spatiotemporal cGMP elevations in synaptic and cognitive functions. At medial perforant path to dentate gyrus (MPP-DG) synapses, we found enhanced long-term potentiation (LTP) of synaptic responses when postsynaptic cGMP was elevated during the induction period.

A Decade-Long Analysis of Trends in Antimicrobial Resistance in a Neurosurgical Hospital in Kathmandu, Nepal.

Multidrug-resistant (MDR) bacteria cause infections with higher risks of morbidity, mortality, and financial burden. Understanding the antimicrobial resistance patterns of these pathogens is crucial for effective treatment and managing resistance. Therefore, this retrospective study examined the prevalence, causes, and trends in antimicrobial resistance in bacterial infections at a neurosurgical hospital in Nepal.

Understanding the Knowledge, Attitude, Practice and Intention regarding Abortion among Federal and Provincial Policymakers.

Background: For more than two decades abortion is legalized in Nepal, recognizing unsafe abortion as one of the leading but preventable cause of maternal morbidity and mortality. To safeguard safe abortion as women’s rights, several policies, guidelines, training manuals have been developed along with training human resources and increasing access to abortion services across Nepal. However, access to safe abortion services remains a challenge.

Synthesis of cefixime loaded PCL/HPMC blend nanoparticles: a controlled release study and anti-bacterial evaluation.

Aim: To enhance cefixime's effectiveness and address drug delivery challenges like concentration at the site, dose, and time, present study investigated the impact of polymer blends on cefixime's release profile.

Methods: Cefixime-loaded nanoparticles were prepared via a modified solvent evaporation method, forming a W/O/W double emulsion. Characterisation included FT-IR, zeta potential, TGA, TEM, and XRD, with in vitro studies and kinetic models used to analyse the release mechanism.