Publications by authors named "J P Munasinghe"
In 2022-2023, a global outbreak of Mpox was reported especially in nonendemic countries. We report the first laboratory-confirmed neonatal case of Mpox infection complicated by bronchopneumonia in Sri Lanka.
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- * Researchers created a mouse model using CRISPR/Cas9 to study the disease, which mimics characteristics seen in human patients, such as specific gait abnormalities and a reduction in motor skills over time.
- * The Glb1 mice also display progressive brain atrophy and increased levels of a pentasaccharide biomarker, supporting their relevance for developing new treatments for GM1 gangliosidosis, particularly the less severe type II variant.
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- Disrupted sleep and excessive daytime sleepiness are common symptoms in brain tumor patients, especially after they undergo radiotherapy, with unclear biological causes.
- Researchers developed a mouse model to study how cranial radiation causes sleep disturbances that mimic human conditions, revealing varying levels of DNA damage across different brain areas.
- Preliminary findings suggest that certain brain regions related to cognitive functions and sleep regulation are particularly sensitive to radiation, which could inform better treatment strategies for patients.
Article Synopsis
- Researchers have discovered a previously unknown transtentorial venous system (TTVS) that connects venous drainage in the human brain, challenging earlier beliefs that this part was mainly avascular.
- The study used mice as a model to investigate the TTVS and found that it is present in adult mice and can be traced back to an embryonic stage where it aids in draining the choroid plexus.
- The findings suggest that the TTVS is conserved between humans and mice, making mice a suitable model for further research into the development and implications of this venous system in brain physiology.