In silico exploration of cholinergic activity and neuroprotection of novel caffeine analogues.

Alzheimer's disease (AD) is characterized by a cholinergic deficit, prompting conventional therapies to elevate acetylcholine levels as a compensatory measure. Two main strategies involve the inhibition of acetylcholinesterase (AChE) and/or the stimulation of acetylcholine receptors (AChR). Caffeine (CFF), known as a partial agonist of nAChR and an AChE inhibitor, acts as a cholinergic enhancer.

Comfort Foods in the Twenty-First Century: Friend or Foe?

The comfort food (CF) concept emerged during the latter half of the twentieth century. Although not well defined, CF can be described as familiar foods that elicit feelings of well-being and play a role in social interactions and psychological health. These foods are often calorically dense and nutrient-poor, and overconsumption of some CF may contribute to negative metabolic health outcomes.

Characterization of Odorants in Clustered Mountain Mint .

The clustered mountain mint, , is a pleasant-smelling, native North American plant. Despite its wide geographical presence across the United States and Canada, little is known about the specific odorants responsible for its pleasing aroma. Herein, 42 odorants were identified in the plant through solvent-assisted flavor evaporation (SAFE), gas chromatography-olfactometry (GC-O), and gas chromatography-mass spectrometry (GC-MS).

Characterization of Odorants in a Commercial Culinary Sage ( L.) and Several Cultivars.

Culinary sage, L., is a popular spice plant commonly used throughout the world. In this study, 35 odorants were identified in dried sage via solvent-assisted flavor evaporation (SAFE) and aroma extract dilution analysis (AEDA), including 9 that were identified in sage for the first time.