High Glucose Sensitizes Male and Female Rat Cardiomyocytes to Wnt/β-Catenin Signaling.

Wnt/β-catenin signaling has been shown to regulate gene expressions in cardiomyocytes. However, it is not known if this effect is dependent on the sex of cells or the glucose level in the culture medium. In the present study, ventricular myocytes were prepared from male and female neonatal rats and maintained in either a glucose-rich (25 mM) medium or a low-glucose (3 mM), lipid-rich medium.

Folded-twisted mechanisms control dynamic redox properties, photophysics and electron transfer of anthanthrene-quinodimethanes.

The synthesis, electrochemical, spectroelectrochemical, photophysical and light induced electron transfer reactions in two new anthanthrene quinodimethanes have been studied and analyzed in the context of dynamic electrochemistry. Their properties are dependent on the interconversion between folded and twisted forms, which are separated by a relatively small energy range, thus allowing to explore their interconversion by variable temperature measurements. The photophysics of these molecules is mediated by a diradical excited state with a twisted structure that habilitates rapid intersystem crossing.

Extended Tetrathiafulvalene Multi-Redox Systems Incorporating 4,5-Dihydroazuleno[2,1,8-ija]azulene Cores.

The introduction of 4,5-dihydroazuleno[2,1,8-ija]azulene as a central core between two 1,4-dithiafulvene (DTF) units provides a novel class of extended tetrathiafulvalene (TTF) electron donors. Herein we present the synthesis of such compounds with the azulenoazulene further expanded by annulation to benzene, naphthalene, or thiophene rings. Moreover, unsymmetrical donor-acceptor chromophores with one DTF and one carbonyl at the central core are presented.

Establishing reliable acceleration-speed profiles: Minimum data requirements in rugby union matches.

The aim of this study was to determine the minimum playing time in matches required to produce reliable acceleration - speed (AS) profiles from global navigation satellite system (GNSS) data. The playing time of 25 professional rugby union players was recorded using GNSS technology and segmented into four sections from 40, 80, 120 and 160 minutes of play. For each interval, the impact of integrating new match data on the AS profile was assessed, aiming to identify the saturation point where additional data did not induce significant changes in the profile outputs.

The Effect of Step Frequency and Running Speed on the Coordination of the Pelvis and Thigh Segments During Running.

This study investigates the specific influence of step frequency (SF) and speed on the coordination between pelvic and thigh movements. Eight recreational male runners ran at different SFs and speeds on an instrumented treadmill. The coordination between the pelvis and thigh segments was analyzed using modified vector coding in the sagittal and frontal planes (FPs).