Publications by authors named "J P McCloskey"
Purpose: The Area Deprivation Index (ADI) is a quantitative measurement of neighborhood socioeconomic disadvantage used to identify high-risk communities. The distribution of physicians with respect to ADI can indicate decreased healthcare access in deprived neighborhoods. This study applies ADI to the distribution of ophthalmologists and demonstrates how practice patterns in the national Medicare Part D program may vary with ADI.
View Article and Find Full Text PDFImportance: Integrated health care systems have initiated major investments to identify and address social risks, particularly for patients with multiple medical conditions.
Objective: To evaluate the association of social risks with health care use among patients with complex multimorbidity.
Design, Setting, And Participants: This longitudinal cohort study assessed Kaiser Permanente Northern California (KPNC) patients with (1) moderate medical complexity (defined by high comorbidity score, high risk of hospitalization, and/or prior emergency department [ED] admissions) and (2) high medical complexity (eg, meeting additional criteria, such as ≥7 medications and laboratory evidence of poor disease control).
Article Synopsis
- Australia implemented a national HPV vaccination program for girls in 2007 and boys in 2013, achieving strong coverage among both groups, with a study focusing on HPV prevalence among men aged 18-35 based on their vaccination status.
- Of the 1,625 men studied, the HPV prevalence was similar for vaccinated and unvaccinated men who have sex with women (10.6% vs. 10.7%), while unvaccinated men who have sex with men had a significantly higher prevalence (40.3%) compared to vaccinated men (29.9%).
- The findings highlight that universal vaccination is crucial for all adolescents, particularly to ensure that men who have sex with men also gain protection from HPV, as older
Article Synopsis
- Social barriers like food insecurity, financial issues, and housing instability can hinder proper health care management for those with chronic illnesses, making it crucial to identify at-risk individuals for proactive support.
- The research aimed to develop a predictive model to identify adults with multiple chronic conditions who may be dealing with these social barriers, using data from Kaiser Permanente Northern California between 2017 and 2020.
- The final model, which utilized 30 predictors, achieved an area under the curve (AUC) of 0.68, indicating moderate effectiveness in predicting those at risk, while being considerate of potential biases related to race and ethnicity. *_
Importance: In newly diagnosed Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL), disease progression due to acquired resistance to first- or second-generation BCR::ABL1 tyrosine kinase inhibitors is common. Ponatinib inhibits BCR::ABL1 and all single-mutation variants, including T315I.
Objective: To compare frontline ponatinib vs imatinib in adults with newly diagnosed Ph+ ALL.