Focused Ultrasound Neuromodulation: Exploring a Novel Treatment for Severe Opioid Use Disorder.

Background: Opioid use disorder remains a critical healthcare challenge as current therapeutic strategies have limitations resulting in high recurrence and deaths. We evaluated safety and feasibility of focused ultrasound (FUS) neuromodulation to reduce substance cravings and use in severe opioid- and co-occurring substance use disorders.

Methods: This prospective, open-label, single-arm study enrolled 8 participants with severe, primary opioid use disorder with co-occurring substance use.

Heritability Estimates of Age at First Calving and Correlation Analysis in Angus Cows Bred in Hungary.

This study aimed to examine the age at first calving (AFC) in Hungarian Angus herds. This study was conducted on the basis of data from 2955 registered cows, classified into five groups (based on different Angus types), and 200 breeding bulls, which were the sires of the cows. The data were made available by the Hungarian Hereford, Angus, and Galloway Breeders' Association.

Exploring the performance of a DOI-capable TOF-PET module using different SiPMs, customized and commercial readout electronics.

Time resolution is crucial in positron emission tomography (PET) to enhance the signal-to-noise ratio and image quality. Moreover, high sensitivity requires long scintillators, which can cause distortions in the reconstructed images due to parallax effects. This study evaluates the performance of a time-of-flight (TOF)-PET module that makes use of a single-side readout of a4×43.

First Stability Characterization for a CZT Detection System in an ee Collider Environment.

The SIDDHARTA-2 collaboration has developed a novel X-ray detection system based on cadmium-zinc-telluride (CZT, CdZnTe), marking the first application of this technology at the DAΦNE electron-positron collider at INFN-LNF. This work aims to demonstrate the stability of the detectors' performance in terms of linearity and resolution over short and long periods, thereby establishing their suitability for precise spectroscopic measurements within a collider environment. A reference calibration spectrum is presented in association with findings from assessments of linearity and resolution stability.

Testing the Pauli Exclusion Principle across the Periodic Table with the VIP-3 Experiment.

The Pauli exclusion principle (PEP), a cornerstone of quantum mechanics and whole science, states that in a system, two fermions can not simultaneously occupy the same quantum state. Several experimental tests have been performed to place increasingly stringent bounds on the validity of PEP. Among these, the series of VIP experiments, performed at the Gran Sasso Underground National Laboratory of INFN, is searching for PEP-violating atomic X-ray transitions in copper.