Publications by authors named "J P Marchaland"
In recent years the applicability domain (AD) of a prediction system has become an important concern in (Q)SAR modelling, especially in the context of human safety assessment. Today AD is an active research topic, and many methods have been designed to estimate the adequacy of a model and the confidence in its outcome for a given prediction task. Unfortunately, the wide spectrum of techniques developed for this purpose is based on various definitions of the concept of AD, often taking into account different types of information.
View Article and Find Full Text PDFArticle Synopsis
- Astrocytes, non-nerve cells in the brain, can secrete substances through vesicles, but their expression is influenced by the REST transcription factor, which typically represses nerve cell functions.
- In experiments with rat astrocytes, high REST levels prevented the expression of dendritic core vesicles (DCVs) until REST was inhibited, leading to the release of specific neuropeptides.
- Human astrocytes showed varying REST levels, which correlated to their different capabilities of producing DCVs, highlighting the complexity and functional diversity of astrocytes in the brain.
The authors report a case of osteoid osteoma distal to a hip prosthesis in a 56-year-old patient. This rare association was difficult to diagnose; at first, the pain seemed to be of mechanical origin, suggesting a delayed painful reaction to the prosthesis. The results of bone scan as well as the CT scan ones helped orient the diagnosis.
View Article and Find Full Text PDFAstrocytes have traditionally been considered ancillary, satellite cells of the nervous system. However, it is a very recent acquisition that glial cells generate signaling loops which are integral to the brain circuitry and participate, interactively with neuronal networks, in the processing of information. Such a conceptual breakthrough makes this field of investigation one of the hottest in neuroscience, as it calls for a revision of past theories of brain function as well as for new strategies of experimental exploration of brain function.
View Article and Find Full Text PDFIntroduction: Posterior shoulder instability is a rare condition, representing only 4% of all shoulder-joint instabilities. Numerous surgical techniques are used to treat it when conservative functional treatment proves to be insufficient. This retrospective study relates to 8 patients, presenting recurrent posterior shoulder instability, all treated with a posterior iliac bone-block procedure.
View Article and Find Full Text PDF