Publications by authors named "J P Lulich"
Background: Nephrocalcinosis is a common pathological finding in cats with chronic kidney disease and nephrolithiasis. Understanding its pathogenesis may identify future therapeutic targets.
Hypothesis: Nephrocalcinosis is associated with expression of an osteogenic phenotype.
Article Synopsis
- A study compared the proteomes of calcium oxalate monohydrate kidney stones in cats and humans, revealing substantial similarities but limited analysis due to a lack of cat urine proteomic data.
- Urine proteome data from 7 healthy cats was gathered and compared to human urine and cat calcium oxalate stone matrices to identify shared enrichment patterns.
- The findings indicated that cat urine proteins showed distribution similarities to human urine, while differences in cat struvite stone matrices suggest distinct mechanisms of stone formation involving both protein interactions and crystal aggregation.
Nutrition plays an important role in shaping the gut microbiome composition, although the impact of diet on the urinary microbiome (i.e., urobiome) remains unknown.
View Article and Find Full Text PDFFirst Reported Case of a Pyrophosphate Kidney Stone in a Human.
Case Rep Nephrol Dial
September 2023
Urolithiasis composed of pyrophosphate salts has only been reported in animals, in the form of potassium magnesium pyrophosphate. However, there have been no reports of pyrophosphate stones in humans. Hypophosphatasia is an inherited disease characterized by low alkaline phosphatase activity and elevated levels of pyrophosphate in blood and urine.
View Article and Find Full Text PDFObjectives: The purpose of this study was to determine changes in urolith trends and factors associated with different urolith types in dogs from the Republic of Ireland and Northern Ireland between 2010 and 2020.
Materials And Methods: A laboratory database was searched for canine urolith submissions between 2010 and 2020. Trends in urolith composition between 2014 and 2020, and associations between patient characteristics with each urolith type were evaluated.