Publications by authors named "J P Lenglet"
Plants are daily challenged by multiple abiotic and biotic stresses. A major biotic constraint corresponds to competition with other plant species. Although plants simultaneously interact with multiple neighboring species throughout their life cycle, there is still very limited information about the genetics of the competitive response in the context of plurispecific interactions.
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- Classical BCR-ABL-negative myeloproliferative neoplasms (MPNs) are disorders caused by mutations in specific genes, primarily affecting hematopoietic stem cells.
- Interferon α (IFNα) has shown potential in inducing remission for MPN patients, and a study involving 48 patients over 5 years assessed its long-term effectiveness by analyzing cell mutations.
- Findings suggest that IFNα is more effective in treating homozygous JAK2V617F mutations and that molecular responses vary with different mutations and dosages of IFNα, indicating a mechanism of HSC exhaustion.
Splenectomy is considered as one of the first-line treatments for symptomatic patients with splenic marginal zone lymphoma (SMZL). Between 1997 and 2012, 100 hepatitis C virus-negative patients with SMZL were treated by splenectomy as first-line treatment. At 6 months, all patients but three recovered from all cytopenias.
View Article and Find Full Text PDFBackground: Rotation thromboelastometry (ROTEM) is an easy, fast and complete method of measuring coagulation.
Aims: Our goal was to obtain longitudinal values on ROTEM in uncomplicated pregnancies and in the puerperium.
Materials And Methods: Healthy women, who visited our outpatient clinic for antenatal checks and who accomplished an uncomplicated pregnancy were tested three times during pregnancy and one time postpartum.
Large granular lymphocyte leukemia (LGL) is characterized by clonal expansion of CD3+ T cells or CD3(-) natural killer cells and frequently is associated with autoimmune diseases. We describe 2 patients with celiac disease who no longer responded to gluten-free diets after they developed T-cell LGL, with intestinal localization of malignant lymphocytes. Flow cytometry phenotyping of isolated intestinal intraepithelial and lamina propria cells eliminated type II refractory celiac disease, identifying large-sized CD8(+)CD57(+) T cells.
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