The Role of Beta-Hydroxybutyrate in Mitigating the Inflammatory and Metabolic Consequences of Uric Acid.

Uric acid (UA), a metabolite of purine and fructose metabolism, is linked to inflammation and metabolic disorders, including gout and cardiovascular disease. Its pro-inflammatory effects are largely driven by the activation of the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome, leading to increased cytokine production. Beta-hydroxybutyrate (BHB), a ketone produced during fasting or carbohydrate restriction, has been shown to reduce inflammation.

Multimorbidity and Its Impact in Older United States Veterans Newly Treated for Advanced Non-Small Cell Lung Cancer.

Rationale: Older adults make up the majority of patients with advanced non-small cell lung cancer (NSCLC) and often carry multiple other comorbidities (multimorbidity) when initiating treatment. The nature and impact of multimorbidity remain largely unknown, given the limitations of standard count-based comorbidity indices in aging patients and their exclusion from clinical trials.

Objective: Our objective is to identify and define multimorbidity patterns in older U.

Changes in Body Mass Index (BMI) during the COVID-19 Pandemic among Indonesian Adolescents: The Role of Sex, Urban Area, Baseline BMI and Appetitive Traits.

Introduction: Little is known about how the COVID-19 situation affected weight development among Indonesian adolescents. This longitudinal study examined whether, and for whom the COVID-19 situation affected weight outcomes over time among adolescents from private schools and higher socioeconomic positions (SEP) in Indonesia, where being overweight is a rather prevalent characteristic. This study specifically examined whether appetitive traits (i.

Mother-newborn couplet care and the expectations, concerns and educational needs of healthcare professionals: a qualitative study.

Objectives: Our aim was to explore healthcare professionals' (HCPs) expectations, concerns and educational needs regarding preparing for implementing the concept of couplet care, keeping newborns in need of intensive care together with their mothers in need of obstetrical care.

Design: A qualitative focus group study based on semistructured interviews. We analysed the data using reflexive thematic analysis.

Methicillin-resistant and methicillin-susceptible in French hedgehogs admitted to a wildlife health center.

The gene conferring methicillin-resistance has always been found on a SCC type XI element and is largely restricted to the few clonal complexes CC130, CC1943, CC425, CC49 and CC599. The occurrence of the gene in many different hosts highlighted its One Health importance, even though European hedgehogs () are considered its natural reservoir, most probably because of the selective pressure imposed by beta-lactam-producing dermatophytes () that colonize the skin of these mammals. Surprisingly, while the presence of on the French territory has been proven, no -positive methicillin-resistant  (MRSA) isolate has been reported yet from hedgehogs.