Publications by authors named "J P LORDAN"
Article Synopsis
- Lung transplantation often leads to chronic lung allograft dysfunction (CLAD), causing immune-related damage and limited long-term survival compared to other organ transplants.
- The E-CLAD UK trial aims to assess if extracorporeal photopheresis (ECP) combined with standard care can better stabilize lung function in CLAD patients than standard care alone.
- This Phase II clinical trial will involve 90 lung transplant patients, with outcomes including lung function changes, exercise capacity, and patient experiences, over a 24-week follow-up period.
Background: N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a biomarker of cardiac ventricular wall stress that is incorporated into pulmonary hypertension (PH) risk stratification models. Sendaway sampling may enable patients to perform NT-proBNP tests remotely. This UK-wide study aimed to assess the agreement of sendaway NT-proBNP with standard venous NT-proBNP and to assess the effect of delayed processing.
View Article and Find Full Text PDFApproved therapies for the treatment of patients with pulmonary arterial hypertension (PAH) mediate pulmonary vascular vasodilatation by targeting distinct biological pathways. International guidelines recommend that patients with an inadequate response to dual therapy with a phosphodiesterase type-5 inhibitor (PDE5i) and endothelin receptor antagonist (ERA), are recommended to either intensify oral therapy by adding a selective prostacyclin receptor (IP) agonist (selexipag), or switching from PDE5i to a soluble guanylate-cyclase stimulator (sGCS; riociguat). The clinical equipoise between these therapeutic choices provides the opportunity for evaluation of individualized therapeutic effects.
View Article and Find Full Text PDFBackground: Lung or heart-lung transplantation (LT/HLT) for severe pulmonary hypertension (PH) as the primary disease indication carries a high risk of waiting list mortality and post-transplant complications. France and the UK both have coordinated PH patient services but with different referral pathways for accessing LT services.
Methods: We conducted a comparative analysis of adult PH patients listed for LT/HLT in the UK and France.
Pulmonary arterial hypertension (PAH) is characterised by pulmonary vascular remodelling causing premature death from right heart failure. Established DNA variants influence PAH risk, but susceptibility from epigenetic changes is unknown. We addressed this through epigenome-wide association study (EWAS), testing 865,848 CpG sites for association with PAH in 429 individuals with PAH and 1226 controls.
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