Publications by authors named "J P Kovalik"
Article Synopsis
- The study investigates how plasma metabolites are linked to the progression of chronic kidney disease in individuals with type 2 diabetes, focusing on kidney function decline measured by eGFR slope.
- Researchers analyzed data from over 5,000 people, identifying specific elevated levels of lipids and amino acids that influence kidney function, both positively and negatively.
- The findings suggest that metabolite abnormalities, particularly related to fatty acids, may indicate issues with fat breakdown and are connected to the risk of worsening kidney health in diabetic patients.
Objective: Bariatric surgery effectively treats non-alcoholic fatty liver disease (NAFLD). The glutamate-serine-glycine (GSG) index has emerged as a non-invasive diagnostic marker for NAFLD, but its ability to monitor treatment response remains unclear. This study investigates the GSG index's ability to monitor NAFLD's response to bariatric surgery.
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- Glycated haemoglobin (HbA1c), a key marker for diabetes, was investigated in older adults without cardiovascular disease to see its role in predicting myocardial ageing.
- A study with 247 participants showed significant correlations between HbA1c levels and various left atrial strain measures, indicating changes in heart function.
- The findings suggest that HbA1c could be a useful biomarker for assessing heart health risks related to ageing, regardless of whether an individual has diabetes.
Glycine is deficient in individuals with obesity but improves following bariatric surgery. Glycine deficiency could impair glutathione (GSH) synthesis and worsen oxidative stress. We examined the impact of obesity-associated glycine deficiency and bariatric surgery on GSH synthesis.
View Article and Find Full Text PDFPurpose: Obesity, defined as abnormal or excessive fat accumulation that presents a risk to health, rose from 8.6 to 10.5% in Singapore's residents.
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